An evil ninja Rider named Fuma appears from the virtual reality world in an effort to conquer Earth! It is up to the CR Riders to use the power of virtual reality gaming to save the day!

The Game World launches an attack on the Real World. In front of Kamen Raidâ Eguzeido (2016) and Uchû Sentai Kyurenjâ (2017) appears the "Arena of Death" where the destruction of the Earth will be decided.

In the early 1990s, experiments were carried out secretly in Japan. Two different methods were used in the experiments. One method involved forcing stress upon expecting parents and when the baby was born, provoke the baby into mutations and develop their special abilities. The other method involved birth to babies having abilities of animals and insects. The special abilities were derived from gene manipulation. Subaru, Saya and others were born from those experiments.